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Undenatured Type II Collagen: Review & Benefits

Posted at March 7th, 2023 | Categorised in Benefit Information

undenatured type ii collagen

What is undenatured type II collagen?

Undenatured type II collagen is the naturally occurring form of type II collagen found in the bodies of humans and animals. Collagen is a structural protein found in various body tissues, including cartilage, skin, tendons, and ligaments.

Type II collagen is mainly found in joint cartilage, which acts as a cushion to reduce friction between bones and helps maintain joint flexibility and strength. Type II collagen is also found in the cartilage of the nose and ears.

UC-II collagen means that the protein is still in its original undamaged structure and form, and this is believed to provide greater health benefits compared to processed or modified forms of collagen.

Several studies have shown that supplements of Collagen type II can help reduce pain in people with osteoarthritis, increase bone density, and improve skin health.

Undenatured Collagen type II elements


undenatured type II collagen

UC-II collagen is a structural protein composed of a variety of important elements, including:

  1. Amino acids: Type II collagen contains amino acids that are essential for building protein, including proline, lysine, glycine, arginine, and alanine.
  2. Helix: Type II collagen consists of three polypeptide chains that form a helix, with each chain having around 1,000 amino acids.
  3. Collagen domains: Each polypeptide chain is composed of collagen domains that contain large amounts of glycosaminoglycan and chondroitin sulfate residues, which are essential for the structure and function of cartilage.
  4. Integrins: Type II collagen also contains integrins, a protein that helps cells interact with the extracellular matrix.
  5. Glycosylation: Sugar groups such as glucose and galactose can combine with collagen type II protein through the process of glycosylation, which affects the structure and function of the protein.

The combination of all these elements is important for forming undenatured type II collagen, which is important for the health of cartilage, skin, and other tissues in the body.

Benefits of undenatured Collagen type II


UC-II collagen may provide several health benefits, including:

  1. Maintains healthy cartilage: Collagen type II is the main component of cartilage, which acts as a cushion to reduce friction between bones and helps maintain joint flexibility and strength. Consumption of undenatured type II collagen can help maintain cartilage health and prevent cartilage damage.
  2. Helps reduce pain in osteoarthritis: Osteoarthritis is a condition that occurs when the cartilage is damaged and becomes inflamed in the joints. Several studies have shown that taking Collagen type II supplements can help reduce pain and improve mobility in people with osteoarthritis.
  3. Increase bone density: The content of type II collagen in bones can help increase bone density and reduce the risk of osteoporosis.
  4. Improve skin health: Collagen type II can help improve skin elasticity and reduce wrinkles. Consuming Collagen type II can also help repair skin damage caused by sun exposure and pollution.

However, further research is still needed to confirm the health benefits of consuming Collagen type II supplements. Remember that undenatured type II collagen supplements should be consumed as part of a healthy diet and should not be used as a substitute for medical treatment prescribed by a doctor.

Research on undenatured type II Collagen


undenatured type II collagen

Undenatured type II collagen has been the subject of research over the last decades. Several studies have shown benefits for joint and cartilage health. Here are some research results on UC-II collagen:

  1. Research published in the journal Osteoarthritis and Cartilage shows that supplements of undenatured type II collagen are effective in reducing pain and increasing mobility in patients with knee osteoarthritis.
  2. A study in the journal Nutrition Research suggests that supplementing with UC-II collagen may help reduce joint pain in patients with rheumatoid arthritis.
  3. An animal study published in the journal Frontiers in Pharmacology shows that UC-II collagen may help prevent cartilage breakdown in mice with osteoarthritis.
  4. A human study in the journal International Journal of Medical Sciences showed that supplementation with Collagen type II can improve the quality of life in patients with osteoarthritis.

However, research on Collagen type II is limited, and more research is needed to more accurately evaluate its benefits and side effects. Also, it is important to note that the results of certain studies may not be applicable to everyone, as each individual has unique health conditions. Therefore, consult your doctor or nutritionist before deciding to take UC-II collagen supplements.

What products contain undenatured Collagen type II?


Collagen type II can be found in several food products and health supplements, including:

  1. Collagen type II supplements: Several health supplement manufacturers offer UC-II collagen supplements as a nutritional source to maintain healthy cartilage and joints.
  2. Seafood: Seafood such as fish, shellfish and crustaceans contain Collagen type II, as well as being rich in nutrients such as protein, omega-3, and vitamin D.
  3. Chicken bones: Raw or boiled chicken bones can be used as a source of UC-II collagen.
  4. Bone broth soup: Bone broth soup resulting from cooking chicken or beef bones can contain UC-II collagen and other nutrients that are important for healthy joints and bones.
  5. Foods and drinks fortified with collagen: Several food and drink manufacturers are now adding collagen to their products, including sports drinks, energy bars, and dessert products.

Several brands of collagen products that claim to contain undenatured type II collagen include:

  1. UC-II Joint Health
  2. Type II Collagen Capsules by BioOptimal
  3. Jarrow Formulas Type II Collagen Complex
  4. Sports Research UC-II Collagen
  5. Youtheory Joint Collagen

The content of undenatured type ii collagen is also found in the Modere Liquid Biocell, you can find complete information on this site.

Be sure to always read product labels and consult your doctor or nutritionist if you have a medical condition or are taking certain medications before deciding to take UC-II Collagen supplements.

How to consume Undenatured Collagen type II?


Undenatured type II collagen is usually available as a supplement that can be taken by mouth or applied topically to the skin. The following are common ways of giving:

  1. Supplements: UC-II collagen supplements can be taken as pills or powders. Dosage and how to use may vary depending on the product used. However, generally, the recommended daily dose ranges from 40-1200 mg per day, depending on individual health conditions. It is best to follow the instructions on the product label or consult a doctor or nutritionist for the correct dosage.
  2. Topical: UC-II collagen products can also be applied to the skin in the form of a gel or cream. These products are usually used to reduce signs of aging on the skin or to improve skin health. How to use may vary depending on the product used. It is best to follow the instructions on the product label or consult a doctor or esthetician for proper use.

Undenatured Type II Collagen side effects


In general, Collagen type II is considered safe for consumption and has no significant side effects at recommended doses. However, in some cases, some people may experience side effects such as:

  1. Indigestion: Some people may experience digestive disturbances such as bloating, diarrhea, or stomach pain when taking collagen supplements. This can happen if a person consumes too high a dose.
  2. Allergic reactions: Some people may experience allergic reactions to undenatured type II collagen. Allergy symptoms can include skin rash, itching, or shortness of breath. If you experience these symptoms after consuming a product containing UC-II Collagen, stop using it immediately and consult a doctor.
  3. Drug interactions: UC-II collagen may affect the effects of certain drugs. Therefore, you should consult your doctor before consuming collagen products if you are currently taking certain medications.

However, it is important to remember that side effects of undenatured type II collagen are very rare and most people can take it without any problems. If you are concerned about possible side effects, consult your doctor or nutritionist before deciding to take UC-II collagen supplements.


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